Beyond networks: rethinking global collaboration in clinical research

The traditional model of global clinical trial execution—dominated by large Contract Research Organizations (CROs)—is increasingly being challenged by new collaborative approaches. In a recent Wemedoo webinar moderated by Valérie Czaya (Chief Operating Officer, Wemedoo), industry experts discussed how the ACROSS Global Alliance is redefining global collaboration by combining centralized coordination with local expertise.

The need for a new model
As highlighted by Nenad Markovic (Alliance Manager, ACROSS Global Alliance), smaller CROs often struggle to access global opportunities due to preferred provider models dominated by large CROs. At the same time, sponsors frequently face challenges such as high costs, inconsistent delivery, and limited flexibility. The alliance model aims to address these gaps by creating a more balanced and scalable approach to global trial execution.

Centralized coordination, local execution
The ACROSS model offers a centralized structure with:

  • a single contracting entity
  • unified governance through a shared Quality Management System (QMS)
  • centralized oversight and communication

At the same time, execution is carried out by local CRO partners with strong regional expertise. According to Kalman Torocsik (President of the Board, Research Professionals CRO; ACROSS Member), this approach allows organizations to focus on high-quality local delivery while benefiting from a structured and globally coordinated framework.

Technology as an enabler
A key component of the model is the use of a shared clinical research information system (Oomnia CTMS), which enables:

  • real-time visibility across studies
  • standardized processes
  • improved decision-making
  • reduced operational fragmentation

This shared infrastructure supports both sponsors and CRO partners by streamlining workflows and improving overall efficiency.

More than a network
As emphasized by Georges Labaki (Chief Executive Officer, Phoenix CRO; Co-founder, Balsam Clinical Research; ACROSS Member), the ACROSS alliance is not simply a referral network. Instead, projects are actively co-delivered, with partners working together using shared systems and aligned quality standards. This results in:

  • faster response times
  • improved communication
  • more predictable study delivery

Benefits for sponsors
The alliance model combines the advantages of global CROs and local providers:

  • single point of contact
  • global reach
  • strong local site relationships
  • cost efficiency
  • operational flexibility

This makes it particularly valuable for small and mid-sized pharmaceutical and biotech companies that require global capabilities without the overhead of large CRO structures.

Looking ahead
The ACROSS Global Alliance represents a shift toward more collaborative, flexible, and integrated models of clinical trial delivery. By combining centralized coordination, advanced technology, and local expertise, it offers a compelling alternative to traditional global CRO models.

Short summary

  • The ACROSS alliance offers an alternative to traditional global CRO models
  • Combines centralized coordination with local CRO expertise
  • Provides a single point of contact for sponsors
  • Enables smaller CROs to participate in global studies
  • Improves cost efficiency, speed, and execution quality
  • Supported by shared systems (QMS, Oomnia CTMS)
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